3. ACUTE, SUBCHRONIC, AND CHRONIC TOXICITY - Exposure and Human Health Reassessment of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) and Related Compounds - Part II
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چکیده
3.1. SCOPE AND LIMITATIONS The acute, subchronic, and chronic toxicology of the chlorinated dioxins, dibenzofurans, biphenyls, and related compounds have been reviewed extensively in recent years. This chapter summarizes knowledge on the toxicology of tetrachlorodibenzo-p-dioxin (TCDD), but also includes references to other dioxin-like compounds when relevant data are available. Included are selected various data that are considered to be of importance to risk assessment, particularly experimental animal data. Immunotoxicity, reproductive/developmental toxicity, carcinogenicity, toxicity to humans, and epidemiology are all covered in other chapters. Ecotoxicology is not covered in this chapter, but examples from mammalian and avian laboratory species are included.
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